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Genomic Characterization of Large Heterochromatic Gaps in the Human Genome Assembly
The largest gaps in the human genome assembly correspond to multi-megabase heterochromatic regions composed primarily of two related families of tandem repeats, Human Satellites 2 and 3 (HSat2,3). The abundance of repetitive DNA in these regions challenges standard mapping and assembly algorithms, a...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022460/ https://www.ncbi.nlm.nih.gov/pubmed/24831296 http://dx.doi.org/10.1371/journal.pcbi.1003628 |