Cargando…

ATPase Subdomain IA Is a Mediator of Interdomain Allostery in Hsp70 Molecular Chaperones

The versatile functions of the heat shock protein 70 (Hsp70) family of molecular chaperones rely on allosteric interactions between their nucleotide-binding and substrate-binding domains, NBD and SBD. Understanding the mechanism of interdomain allostery is essential to rational design of Hsp70 modul...

Descripción completa

Detalles Bibliográficos
Autores principales:	General, Ignacio J., Liu, Ying, Blackburn, Mandy E., Mao, Wenzhi, Gierasch, Lila M., Bahar, Ivet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022485/ https://www.ncbi.nlm.nih.gov/pubmed/24831085 http://dx.doi.org/10.1371/journal.pcbi.1003624

Ejemplares similares

An interdomain sector mediating allostery in Hsp70 molecular chaperones
por: Smock, Robert G, et al.
Publicado: (2010)

Role of Hsp70 ATPase Domain Intrinsic Dynamics and Sequence Evolution in Enabling its Functional Interactions with NEFs
por: Liu, Ying, et al.
Publicado: (2010)

Key features of an Hsp70 chaperone allosteric landscape revealed by ion-mobility native mass spectrometry and double electron-electron resonance
por: Lai, Alex L., et al.
Publicado: (2017)

Alternative ATPase domain interactions in eukaryotic Hsp70 chaperones
por: Ben-Khoud, Yassin, et al.
Publicado: (2023)

Insights into the molecular mechanism of allostery in Hsp70s
por: Mayer, Matthias P., et al.
Publicado: (2015)

Cooperative Assembly of Hsp70 Subdomain Clusters
por: Wright, Maya A., et al.
Publicado: (2018)

Physics-based modeling provides predictive understanding of selectively promiscuous substrate binding by Hsp70 chaperones
por: Nordquist, Erik B., et al.
Publicado: (2021)

Modeling of the Full-Size 3D Structure of Human Chaperone Hsp70 and Study of Its Interdomain Interactions
por: Chernorizov, К. А., et al.
Publicado: (2010)

Ligand-specific conformational change drives interdomain allostery in Pin1
por: Born, Alexandra, et al.
Publicado: (2022)

Conformational dynamics of the Hsp70 chaperone throughout key steps of its ATPase cycle
por: Rohland, Lukas, et al.
Publicado: (2022)

ATPase Activity and ATP-dependent Conformational Change in the Co-chaperone HSP70/HSP90-organizing Protein (HOP)
por: Yamamoto, Soh, et al.
Publicado: (2014)

Hsp70 Oligomerization Is Mediated by an Interaction between the Interdomain Linker and the Substrate-Binding Domain
por: Aprile, Francesco A., et al.
Publicado: (2013)

Biogenesis of the mitochondrial Hsp70 chaperone
por: Blamowska, Marta, et al.
Publicado: (2012)

The Hsp70-Chaperone Machines in Bacteria
por: Mayer, Matthias P.
Publicado: (2021)

Hsp110 Chaperones Control Client Fate Determination in the Hsp70–Hsp90 Chaperone System
por: Mandal, Atin K., et al.
Publicado: (2010)

The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases
por: Lackie, Rachel E., et al.
Publicado: (2017)

Review: The HSP90 molecular chaperone—an enigmatic ATPase
por: Pearl, Laurence H.
Publicado: (2016)

Pathways of allosteric regulation in Hsp70 chaperones
por: Kityk, Roman, et al.
Publicado: (2015)

Editorial: The HSP70 Molecular Chaperone Machines
por: Goloubinoff, Pierre
Publicado: (2017)

Alterations of the Hsp70/Hsp90 chaperone and the HOP/CHIP co-chaperone system in cancer
por: Ruckova, Eva, et al.
Publicado: (2012)

Cooperation of Hsp70 and Hsp100 chaperone machines in protein disaggregation
por: Mogk, Axel, et al.
Publicado: (2015)

The Chaperone System in Breast Cancer: Roles and Therapeutic Prospects of the Molecular Chaperones Hsp27, Hsp60, Hsp70, and Hsp90
por: Alberti, Giusi, et al.
Publicado: (2022)

Tamoxifen Enhances the Hsp90 Molecular Chaperone ATPase Activity
por: Zhao, Rongmin, et al.
Publicado: (2010)

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition
por: Ogden, Tom E H, et al.
Publicado: (2021)

Hsp70 chaperones: Cellular functions and molecular mechanism
por: Mayer, M. P., et al.
Publicado: (2005)

The nucleotide exchange factors of Hsp70 molecular chaperones
por: Bracher, Andreas, et al.
Publicado: (2015)

Theory of Allosteric Regulation in Hsp70 Molecular Chaperones
por: Hendrickson, Wayne A.
Publicado: (2020)

Hsp70 and Hsp110 Chaperones Promote Early Steps of Proteasome Assembly
por: Matias, Ana C., et al.
Publicado: (2022)

Changes in Dynamics upon Oligomerization Regulate Substrate Binding and Allostery in Amino Acid Kinase Family Members
por: Marcos, Enrique, et al.
Publicado: (2011)

Natural Iminosugar (+)-Lentiginosine Inhibits ATPase and Chaperone Activity of Hsp90
por: Dal Piaz, Fabrizio, et al.
Publicado: (2012)

Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism
por: Schulze, Andrea, et al.
Publicado: (2016)

Identification of Key Hinge Residues Important for Nucleotide-Dependent Allostery in E. coli Hsp70/DnaK
por: Ung, Peter Man-Un, et al.
Publicado: (2013)

Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation
por: Winkler, Juliane, et al.
Publicado: (2012)

HSP70 and HSP90 in Cancer: Cytosolic, Endoplasmic Reticulum and Mitochondrial Chaperones of Tumorigenesis
por: Albakova, Zarema, et al.
Publicado: (2022)

Folding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease
por: Rutledge, Benjamin S., et al.
Publicado: (2022)

Multitasking of Hsp70 chaperone in the biogenesis of bacterial functional amyloids
por: Sugimoto, Shinya, et al.
Publicado: (2018)

Hsp70 chaperone: a master player in protein homeostasis
por: Fernández-Fernández, María Rosario, et al.
Publicado: (2018)

Heat shock-induced chaperoning by Hsp70 is enabled in-cell
por: Guin, Drishti, et al.
Publicado: (2019)

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells
por: Ryu, Seung W., et al.
Publicado: (2020)

Chaperoning Proteins for Destruction: Diverse Roles of Hsp70 Chaperones and their Co-Chaperones in Targeting Misfolded Proteins to the Proteasome
por: Shiber, Ayala, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_6kf3e1nu1upgn3v7cohdk9h888