The C-Terminal Random Coil Region Tunes the Ca(2+)-Binding Affinity of S100A4 through Conformational Activation

S100A4 interacts with many binding partners upon Ca(2+) activation and is strongly associated with increased metastasis formation. In order to understand the role of the C-terminal random coil for the protein function we examined how small angle X-ray scattering of the wild-type S100A4 and its C-ter...

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Detalles Bibliográficos
Autores principales: Duelli, Annette, Kiss, Bence, Lundholm, Ida, Bodor, Andrea, Petoukhov, Maxim V., Svergun, Dmitri I., Nyitray, László, Katona, Gergely
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022583/
https://www.ncbi.nlm.nih.gov/pubmed/24830809
http://dx.doi.org/10.1371/journal.pone.0097654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022583/
https://www.ncbi.nlm.nih.gov/pubmed/24830809
http://dx.doi.org/10.1371/journal.pone.0097654

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