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The C-Terminal Random Coil Region Tunes the Ca(2+)-Binding Affinity of S100A4 through Conformational Activation
S100A4 interacts with many binding partners upon Ca(2+) activation and is strongly associated with increased metastasis formation. In order to understand the role of the C-terminal random coil for the protein function we examined how small angle X-ray scattering of the wild-type S100A4 and its C-ter...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022583/ https://www.ncbi.nlm.nih.gov/pubmed/24830809 http://dx.doi.org/10.1371/journal.pone.0097654 |