B-Ring-Aryl Substituted Luotonin A Analogues with a New Binding Mode to the Topoisomerase 1-DNA Complex Show Enhanced Cytotoxic Activity

Topoisomerase 1 inhibition is an important strategy in targeted cancer chemotherapy. The drugs currently in use acting on this enzyme belong to the family of the camptothecins, and suffer severe limitations because of their low stability, which is associated with the hydrolysis of the δ-lactone moie...

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Detalles Bibliográficos
Autores principales: González-Ruiz, Víctor, Pascua, Irene, Fernández-Marcelo, Tamara, Ribelles, Pascual, Bianchini, Giulia, Sridharan, Vellaisamy, Iniesta, Pilar, Ramos, M. Teresa, Olives, Ana I., Martín, M. Antonia, Menéndez, J. Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022624/
https://www.ncbi.nlm.nih.gov/pubmed/24830682
http://dx.doi.org/10.1371/journal.pone.0095998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022624/
https://www.ncbi.nlm.nih.gov/pubmed/24830682
http://dx.doi.org/10.1371/journal.pone.0095998

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