Cargando…

B-Ring-Aryl Substituted Luotonin A Analogues with a New Binding Mode to the Topoisomerase 1-DNA Complex Show Enhanced Cytotoxic Activity

Topoisomerase 1 inhibition is an important strategy in targeted cancer chemotherapy. The drugs currently in use acting on this enzyme belong to the family of the camptothecins, and suffer severe limitations because of their low stability, which is associated with the hydrolysis of the δ-lactone moie...

Descripción completa

Detalles Bibliográficos
Autores principales:	González-Ruiz, Víctor, Pascua, Irene, Fernández-Marcelo, Tamara, Ribelles, Pascual, Bianchini, Giulia, Sridharan, Vellaisamy, Iniesta, Pilar, Ramos, M. Teresa, Olives, Ana I., Martín, M. Antonia, Menéndez, J. Carlos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022624/ https://www.ncbi.nlm.nih.gov/pubmed/24830682 http://dx.doi.org/10.1371/journal.pone.0095998

Ejemplares similares

D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity
por: Almansour, Abdulrahman I., et al.
Publicado: (2019)

Recent Advances in the Studies on Luotonins
por: Liang, Jing Lu, et al.
Publicado: (2011)

A Facile Oxidative Opening of the C-Ring in Luotonin A and Derivatives
por: Ibric, Amra, et al.
Publicado: (2017)

Weinreb Amidation as the Cornerstone of an Improved Synthetic Route to A-Ring-Modified Derivatives of Luotonin A
por: Haider, Norbert, et al.
Publicado: (2012)

Position-Selective Synthesis and Biological Evaluation of Four Isomeric A-Ring Amino Derivatives of the Alkaloid Luotonin A
por: Ibric, Amra, et al.
Publicado: (2019)

Fluorescence Sensors Based on Hydroxycarbazole for the Determination of Neurodegeneration-Related Halide Anions
por: González-Ruiz, Víctor, et al.
Publicado: (2022)

Antioxidants as Molecular Probes: Structurally Novel Dihydro-m-Terphenyls as Turn-On Fluorescence Chemodosimeters for Biologically Relevant Oxidants
por: González-Ruiz, Víctor, et al.
Publicado: (2020)

Enhanced Stability and Bioactivity of Natural Anticancer Topoisomerase I Inhibitors through Cyclodextrin Complexation
por: González-Ruiz, Víctor, et al.
Publicado: (2021)

Aryl substitution of pentacenes
por: Waterloo, Andreas R, et al.
Publicado: (2014)

Synthesis and Anticancer Activity of N-Aryl-5-substituted-1,3,4-oxadiazol-2-amine Analogues
por: Ahsan, Mohamed Jawed, et al.
Publicado: (2014)

Bisavenathramide Analogues as Nrf2 Inductors and Neuroprotectors in In Vitro Models of Oxidative Stress and Hyperphosphorylation
por: Cores, Ángel, et al.
Publicado: (2021)

Study of Genotoxicity, Activities on Caspase 8 and on the Stabilization of the Topoisomerase Complex of Isoeleutherin and Analogues
por: de Albuquerque, Kelly Cristina Oliveira, et al.
Publicado: (2023)

An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues
por: Ghozlan, Said A S, et al.
Publicado: (2007)

Nickel-catalyzed arylative substitution of homoallylic alcohols
por: Tran, Hai N., et al.
Publicado: (2022)

Brominated Thiophenes as Precursors in the Preparation of Brominated and Arylated Anthraquinones
por: Thiemann, Thies, et al.
Publicado: (2009)

SAR of Novel 3-Arylisoquinolinones: meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules
por: Elhemely, Mai A., et al.
Publicado: (2022)

Generation of Aryl Radicals from Aryl Hydrazines via Catalytic Iodine in Air: Arylation of Substituted 1,4-Naphthoquinones
por: Sar, Saibal, et al.
Publicado: (2020)

Cytotoxic Activity, Topoisomerase I Inhibition and In Silico Studies of New Sesquiterpene-aryl Ester Derivatives of (-) Drimenol
por: Araque, Ileana, et al.
Publicado: (2023)

Aryl-substituted acridanes as hosts for TADF-based OLEDs
por: Masimukku, Naveen, et al.
Publicado: (2020)

Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue
por: Chène, Patrick, et al.
Publicado: (2009)

QSAR Modeling on Benzo[c]phenanthridine Analogues as Topoisomerase I Inhibitors and Anti-cancer Agents
por: Thai, Khac-Minh, et al.
Publicado: (2012)

Silylium‐Ion‐Promoted (5+1) Cycloaddition of Aryl‐Substituted Vinylcyclopropanes and Hydrosilanes Involving Aryl Migration
por: He, Tao, et al.
Publicado: (2020)

Exploring BenzylethoxyAryl Urea Scaffolds for Multitarget Immunomodulation Therapies
por: Gil-Edo, Raquel, et al.
Publicado: (2023)

The X-Ray Crystal Structures of Primary Aryl Substituted Selenoamides
por: Li, Yang, et al.
Publicado: (2009)

Direct catalytic arylation of heteroarenes with meso-bromophenyl-substituted porphyrins
por: Kiselev, Alexei Nikolaevich, et al.
Publicado: (2017)

An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones
por: Aksenov, Dmitrii A., et al.
Publicado: (2023)

Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions
por: Babaev, Eugene V, et al.
Publicado: (2005)

Novel Penicillin-Type Analogues Bearing a Variable Substituted 2-Azetidinone Ring at Position 6: Synthesis and Biological Evaluation
por: De Rosa, Margherita, et al.
Publicado: (2015)

N-Aryl-3,4-dihydroisoquinoline Carbothioamide Analogues as Potential Urease Inhibitors
por: Ali, Fayaz, et al.
Publicado: (2021)

A palladium-catalyzed synthesis of (hetero)aryl-substituted imidazoles from aryl halides, imines and carbon monoxide
por: Tjutrins, Jevgenijs, et al.
Publicado: (2017)

Substituted 4,5′-Bithiazoles as Catalytic Inhibitors of Human DNA Topoisomerase IIα
por: Bergant Loboda, Kaja, et al.
Publicado: (2020)

Aryl Urea Based Scaffolds for Multitarget Drug Discovery in Anticancer Immunotherapies
por: Martín-Beltrán, Celia, et al.
Publicado: (2021)

Stereospecific Cross-Coupling Reactions of Aryl-Substituted Tetrahydrofurans, Tetrahydropyrans, and Lactones
por: Tollefson, Emily J., et al.
Publicado: (2014)

New 1-Aryl-3-Substituted Propanol Derivatives as Antimalarial Agents
por: Pérez-Silanes, Silvia, et al.
Publicado: (2009)

A Triazole‐Substituted Aryl Iodide with Omnipotent Reactivity in Enantioselective Oxidations
por: Abazid, Ayham H., et al.
Publicado: (2019)

Amino-Substituted 3-Aryl- and 3-Heteroarylquinolines as Potential Antileishmanial Agents
por: Hammill, Jared T., et al.
Publicado: (2021)

Prospects and Applications of Palladium Nanoparticles in the Cross‐coupling of (hetero)aryl Halides and Related Analogues
por: Ayogu, Jude I., et al.
Publicado: (2021)

Design, Synthesis and Antifungal Activities of Novel Pyrazole Analogues Containing the Aryl Trifluoromethoxy Group
por: Zhao, Tongchao, et al.
Publicado: (2023)

Carboxylate-functionalized foldamer inhibitors of HIV-1 integrase and Topoisomerase 1: artificial analogues of DNA mimic proteins
por: Corvaglia, Valentina, et al.
Publicado: (2019)

A Support Vector Machine Classification Model for Benzo[c]phenathridine Analogues with Topoisomerase-I Inhibitory Activity
por: Thai, Khac-Minh, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_sarevid5eb8ki2h8ucq11899s8