The Mechanism of Allosteric Inhibition of Protein Tyrosine Phosphatase 1B

As the prototypical member of the PTP family, protein tyrosine phosphatase 1B (PTP1B) is an attractive target for therapeutic interventions in type 2 diabetes. The extremely conserved catalytic site of PTP1B renders the design of selective PTP1B inhibitors intractable. Although discovered allosteric...

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Detalles Bibliográficos
Autores principales: Li, Shuai, Zhang, Jingmiao, Lu, Shaoyong, Huang, Wenkang, Geng, Lv, Shen, Qiancheng, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022711/
https://www.ncbi.nlm.nih.gov/pubmed/24831294
http://dx.doi.org/10.1371/journal.pone.0097668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022711/
https://www.ncbi.nlm.nih.gov/pubmed/24831294
http://dx.doi.org/10.1371/journal.pone.0097668

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