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Papillomavirus Genomes Associate with BRD4 to Replicate at Fragile Sites in the Host Genome
It has long been recognized that oncogenic viruses often integrate close to common fragile sites. The papillomavirus E2 protein, in complex with BRD4, tethers the viral genome to host chromatin to ensure persistent replication. Here, we map these targets to a number of large regions of the human gen...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022725/ https://www.ncbi.nlm.nih.gov/pubmed/24832099 http://dx.doi.org/10.1371/journal.ppat.1004117 |