Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis

In amyotrophic lateral sclerosis (ALS), mitochondrial dysfunction is recognized as one of the key elements contributing to the pathology. Mitochondria are the major source of intracellular reactive oxygen species (ROS). Increased production of ROS as well as oxidative damage of proteins and lipids h...

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Detalles Bibliográficos
Autores principales: Vehviläinen, Piia, Koistinaho, Jari, Gundars, Goldsteins
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023018/
https://www.ncbi.nlm.nih.gov/pubmed/24847211
http://dx.doi.org/10.3389/fncel.2014.00126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023018/
https://www.ncbi.nlm.nih.gov/pubmed/24847211
http://dx.doi.org/10.3389/fncel.2014.00126

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