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Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis
In amyotrophic lateral sclerosis (ALS), mitochondrial dysfunction is recognized as one of the key elements contributing to the pathology. Mitochondria are the major source of intracellular reactive oxygen species (ROS). Increased production of ROS as well as oxidative damage of proteins and lipids h...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023018/ https://www.ncbi.nlm.nih.gov/pubmed/24847211 http://dx.doi.org/10.3389/fncel.2014.00126 |