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Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons
BACKGROUND: Fragmentation of stacked cisterns of the Golgi apparatus into dispersed smaller elements is a feature associated with degeneration of neurons in amyotrophic lateral sclerosis (ALS) and some other neurodegenerative disorders. However, the role of Golgi fragmentation in motor neuron degene...
Autores principales: | van Dis, Vera, Kuijpers, Marijn, Haasdijk, Elize D, Teuling, Eva, Oakes, Scott A, Hoogenraad, Casper C, Jaarsma, Dick |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023628/ https://www.ncbi.nlm.nih.gov/pubmed/24708899 http://dx.doi.org/10.1186/2051-5960-2-38 |
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