Identification of Metabolites, Clinical Chemistry Markers and Transcripts Associated with Hepatotoxicity

Early and accurate pre-clinical and clinical biomarkers of hepatotoxicity facilitate the drug development process and the safety monitoring in clinical studies. We selected eight known model compounds to be administered to male Wistar rats to identify biomarkers of drug induced liver injury (DILI) u...

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Detalles Bibliográficos
Autores principales: Buness, Andreas, Roth, Adrian, Herrmann, Annika, Schmitz, Oliver, Kamp, Hennicke, Busch, Kristina, Suter, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023975/
https://www.ncbi.nlm.nih.gov/pubmed/24836604
http://dx.doi.org/10.1371/journal.pone.0097249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023975/
https://www.ncbi.nlm.nih.gov/pubmed/24836604
http://dx.doi.org/10.1371/journal.pone.0097249

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