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Identification of Metabolites, Clinical Chemistry Markers and Transcripts Associated with Hepatotoxicity
Early and accurate pre-clinical and clinical biomarkers of hepatotoxicity facilitate the drug development process and the safety monitoring in clinical studies. We selected eight known model compounds to be administered to male Wistar rats to identify biomarkers of drug induced liver injury (DILI) u...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023975/ https://www.ncbi.nlm.nih.gov/pubmed/24836604 http://dx.doi.org/10.1371/journal.pone.0097249 |