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Detection of driver metabolites in the human liver metabolic network using structural controllability analysis

BACKGROUND: Abnormal states in human liver metabolism are major causes of human liver diseases ranging from hepatitis to hepatic tumor. The accumulation in relevant data makes it feasible to derive a large-scale human liver metabolic network (HLMN) and to discover important biological principles or...

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Detalles Bibliográficos
Autores principales: Liu, Xueming, Pan, Linqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024020/
https://www.ncbi.nlm.nih.gov/pubmed/24885538
http://dx.doi.org/10.1186/1752-0509-8-51