Lack of Correlation between the Kinase Activity of LRRK2 Harboring Kinase-Modifying Mutations and Its Phosphorylation at Ser910, 935, and Ser955

Leucine-rich repeat kinase 2 (LRRK2) is extensively phosphorylated in cells within a region amino-terminal to the leucine-rich repeat domain. Since phosphorylation in this region of LRRK2, including Ser910, Ser935, Ser955, and Ser973, is significantly downregulated upon treatment with inhibitors of...

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Detalles Bibliográficos
Autores principales: Ito, Genta, Fujimoto, Tetta, Kamikawaji, Shogo, Kuwahara, Tomoki, Iwatsubo, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024040/
https://www.ncbi.nlm.nih.gov/pubmed/24836358
http://dx.doi.org/10.1371/journal.pone.0097988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024040/
https://www.ncbi.nlm.nih.gov/pubmed/24836358
http://dx.doi.org/10.1371/journal.pone.0097988

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