A graph theoretic approach to utilizing protein structure to identify non-random somatic mutations

BACKGROUND: It is well known that the development of cancer is caused by the accumulation of somatic mutations within the genome. For oncogenes specifically, current research suggests that there is a small set of "driver" mutations that are primarily responsible for tumorigenesis. Further,...

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Detalles Bibliográficos
Autores principales: Ryslik, Gregory A, Cheng, Yuwei, Cheung, Kei-Hoi, Modis, Yorgo, Zhao, Hongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024121/
https://www.ncbi.nlm.nih.gov/pubmed/24669769
http://dx.doi.org/10.1186/1471-2105-15-86

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024121/
https://www.ncbi.nlm.nih.gov/pubmed/24669769
http://dx.doi.org/10.1186/1471-2105-15-86

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