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Epistasis and Natural Selection Shape the Mutational Architecture of Complex Traits
The evolutionary trajectories of complex traits are constrained by levels of genetic variation as well as genetic correlations among traits. Because the ultimate source of all genetic variation is mutation, the distribution of mutations entering populations profoundly affects standing variation and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024485/ https://www.ncbi.nlm.nih.gov/pubmed/24828461 http://dx.doi.org/10.1038/ncomms4709 |
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author | Jones, Adam G. Bürger, Reinhard Arnold, Stevan J. |
author_facet | Jones, Adam G. Bürger, Reinhard Arnold, Stevan J. |
author_sort | Jones, Adam G. |
collection | PubMed |
description | The evolutionary trajectories of complex traits are constrained by levels of genetic variation as well as genetic correlations among traits. Because the ultimate source of all genetic variation is mutation, the distribution of mutations entering populations profoundly affects standing variation and genetic correlations. Here, we use an individual-based simulation model to investigate how natural selection and gene interactions (i.e., epistasis) shape the evolution of mutational processes affecting complex traits. We find that the presence of epistasis allows natural selection to mold the distribution of mutations, such that mutational effects align with the selection surface. Consequently, novel mutations tend to be more compatible with the current forces of selection acting on the population. These results suggest that in many cases mutational effects should be seen as an outcome of natural selection rather than as an unbiased source of genetic variation that is independent of other evolutionary processes. |
format | Online Article Text |
id | pubmed-4024485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
record_format | MEDLINE/PubMed |
spelling | pubmed-40244852014-11-14 Epistasis and Natural Selection Shape the Mutational Architecture of Complex Traits Jones, Adam G. Bürger, Reinhard Arnold, Stevan J. Nat Commun Article The evolutionary trajectories of complex traits are constrained by levels of genetic variation as well as genetic correlations among traits. Because the ultimate source of all genetic variation is mutation, the distribution of mutations entering populations profoundly affects standing variation and genetic correlations. Here, we use an individual-based simulation model to investigate how natural selection and gene interactions (i.e., epistasis) shape the evolution of mutational processes affecting complex traits. We find that the presence of epistasis allows natural selection to mold the distribution of mutations, such that mutational effects align with the selection surface. Consequently, novel mutations tend to be more compatible with the current forces of selection acting on the population. These results suggest that in many cases mutational effects should be seen as an outcome of natural selection rather than as an unbiased source of genetic variation that is independent of other evolutionary processes. 2014-05-14 /pmc/articles/PMC4024485/ /pubmed/24828461 http://dx.doi.org/10.1038/ncomms4709 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Jones, Adam G. Bürger, Reinhard Arnold, Stevan J. Epistasis and Natural Selection Shape the Mutational Architecture of Complex Traits |
title | Epistasis and Natural Selection Shape the Mutational Architecture of Complex Traits |
title_full | Epistasis and Natural Selection Shape the Mutational Architecture of Complex Traits |
title_fullStr | Epistasis and Natural Selection Shape the Mutational Architecture of Complex Traits |
title_full_unstemmed | Epistasis and Natural Selection Shape the Mutational Architecture of Complex Traits |
title_short | Epistasis and Natural Selection Shape the Mutational Architecture of Complex Traits |
title_sort | epistasis and natural selection shape the mutational architecture of complex traits |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024485/ https://www.ncbi.nlm.nih.gov/pubmed/24828461 http://dx.doi.org/10.1038/ncomms4709 |
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