A TALEN-based strategy for efficient bi-allelic miRNA ablation in human cells

Significant progress in the functional understanding of microRNAs (miRNAs) has been made in mice, but a need remains to develop efficient tools for bi-allelic knockouts of miRNA in the human genome. Transcription activator-like effector nucleases (TALENs) provide an exciting platform for targeted ge...

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Detalles Bibliográficos
Autores principales: Uhde-Stone, Claudia, Sarkar, Nandita, Antes, Travis, Otoc, Nicole, Kim, Young, Jiang, Yan J., Lu, Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024647/
https://www.ncbi.nlm.nih.gov/pubmed/24717974
http://dx.doi.org/10.1261/rna.042010.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024647/
https://www.ncbi.nlm.nih.gov/pubmed/24717974
http://dx.doi.org/10.1261/rna.042010.113

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