Transcription factor IRF5 drives P2X4R(+)-reactive microglia gating neuropathic pain

In response to neuronal injury or disease, microglia adopt distinct reactive phenotypes via the expression of different sets of genes. Spinal microglia expressing the purinergic P2X4 receptor (P2X4R) after peripheral nerve injury (PNI) are implicated in neuropathic pain. Here we show that interferon...

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Detalles Bibliográficos
Autores principales: Masuda, Takahiro, Iwamoto, Shosuke, Yoshinaga, Ryohei, Tozaki-Saitoh, Hidetoshi, Nishiyama, Akira, Mak, Tak W., Tamura, Tomohiko, Tsuda, Makoto, Inoue, Kazuhide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024744/
https://www.ncbi.nlm.nih.gov/pubmed/24818655
http://dx.doi.org/10.1038/ncomms4771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024744/
https://www.ncbi.nlm.nih.gov/pubmed/24818655
http://dx.doi.org/10.1038/ncomms4771

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