Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy

Endosomal protein sorting controls the localization of many physiologically important proteins and is linked to several neurodegenerative diseases. VPS35 is a component of the retromer complex, which mediates endosome-to-Golgi retrieval of membrane proteins such as the cation-independent mannose 6-p...

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Detalles Bibliográficos
Autores principales: Zavodszky, Eszter, Seaman, Matthew N.J., Moreau, Kevin, Jimenez-Sanchez, Maria, Breusegem, Sophia Y., Harbour, Michael E., Rubinsztein, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024763/
https://www.ncbi.nlm.nih.gov/pubmed/24819384
http://dx.doi.org/10.1038/ncomms4828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024763/
https://www.ncbi.nlm.nih.gov/pubmed/24819384
http://dx.doi.org/10.1038/ncomms4828

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