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Protective role of human insulin against the cytotoxicity associated with human mutant S20G islet amyloid polypeptide
AIMS/INTRODUCTION: Islet amyloid polypeptide (IAPP) is a main component of islet amyloid in type 2 diabetes and cosecreted from β‐cell with insulin. Clinical evidence from the patients with S20G mutation of the IAPP gene, as well as experimental evidence that insulin could inhibit amyloid formation...
Autores principales: | Morita, Shuhei, Ueyama, Minoru, Sakagashira, Setsuya, Shimajiri, Yoshinori, Yamana, Akiko, Furuta, Machi, Sanke, Tokio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley-Blackwell
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025108/ https://www.ncbi.nlm.nih.gov/pubmed/24843692 http://dx.doi.org/10.1111/jdi.12069 |
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