Palmitate induces reactive oxygen species production and β‐cell dysfunction by activating nicotinamide adenine dinucleotide phosphate oxidase through Src signaling

AIMS/INTRODUCTION: Chronic hyperlipidemia impairs pancreatic β‐cell function, referred to as lipotoxicity. We have reported an important role of endogenous reactive oxygen species (ROS) overproduction by activation of Src, a non‐receptor tyrosine kinase, in impaired glucose‐induced insulin secretion...

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Detalles Bibliográficos
Autores principales: Sato, Yuichi, Fujimoto, Shimpei, Mukai, Eri, Sato, Hiroki, Tahara, Yumiko, Ogura, Kasane, Yamano, Gen, Ogura, Masahito, Nagashima, Kazuaki, Inagaki, Nobuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley-Blackwell 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025235/
https://www.ncbi.nlm.nih.gov/pubmed/24843732
http://dx.doi.org/10.1111/jdi.12124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025235/
https://www.ncbi.nlm.nih.gov/pubmed/24843732
http://dx.doi.org/10.1111/jdi.12124

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