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Sugars, sucrose and colorectal cancer risk: the Fukuoka colorectal cancer study

OBJECTIVE: A diet high in sugars may promote colorectal carcinogenesis, but it remains uncertain whether high intake of sugars or sucrose confers increased risk of colorectal cancer. The authors investigated the associations of sugars and sucrose intake with colorectal cancer risk in a community-bas...

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Autores principales: Wang, Zhenjie, Uchida, Kazuhiro, Ohnaka, Keizo, Morita, Makiko, Toyomura, Kengo, Kono, Suminori, Ueki, Takashi, Tanaka, Masao, Kakeji, Yoshihiro, Maehara, Yoshihiko, Okamura, Takeshi, Ikejiri, Koji, Futami, Kitaroh, Maekawa, Takafumi, Yasunami, Yohichi, Takenaka, Kenji, Ichimiya, Hitoshi, Terasaka, Reiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025586/
https://www.ncbi.nlm.nih.gov/pubmed/24716480
http://dx.doi.org/10.3109/00365521.2013.822091
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author Wang, Zhenjie
Uchida, Kazuhiro
Ohnaka, Keizo
Morita, Makiko
Toyomura, Kengo
Kono, Suminori
Ueki, Takashi
Tanaka, Masao
Kakeji, Yoshihiro
Maehara, Yoshihiko
Okamura, Takeshi
Ikejiri, Koji
Futami, Kitaroh
Maekawa, Takafumi
Yasunami, Yohichi
Takenaka, Kenji
Ichimiya, Hitoshi
Terasaka, Reiji
author_facet Wang, Zhenjie
Uchida, Kazuhiro
Ohnaka, Keizo
Morita, Makiko
Toyomura, Kengo
Kono, Suminori
Ueki, Takashi
Tanaka, Masao
Kakeji, Yoshihiro
Maehara, Yoshihiko
Okamura, Takeshi
Ikejiri, Koji
Futami, Kitaroh
Maekawa, Takafumi
Yasunami, Yohichi
Takenaka, Kenji
Ichimiya, Hitoshi
Terasaka, Reiji
author_sort Wang, Zhenjie
collection PubMed
description OBJECTIVE: A diet high in sugars may promote colorectal carcinogenesis, but it remains uncertain whether high intake of sugars or sucrose confers increased risk of colorectal cancer. The authors investigated the associations of sugars and sucrose intake with colorectal cancer risk in a community-based case–control study in Japan. METHODS: The study subjects comprised 816 incident cases of colorectal cancer and 815 community controls. Consumption frequencies and portion sizes of 148 food and beverage items were ascertained by a computer-assisted interview. The authors used the consumption of 29 food items to estimate sugars and sucrose intake. The odds ratios of colorectal cancer risk according to intake categories were obtained using a logistic regression model with adjustment for potential confounding variables. RESULTS: Overall, intakes of sugars and sucrose were not related to colorectal cancer risk either in men or women. The association between sugars intake and colorectal cancer risk differed by smoking status and alcohol use in men, but not in women. In men, sugars intake tended to be associated with colorectal cancer risk inversely among never-smokers and positively among male ever-smokers (interaction p = 0.01). Sugars intake was associated with an increased risk among men with no alcohol consumption, but was unrelated to the risk among male alcohol drinkers (interaction p = 0.02). Body mass index did not modify the association with sugars intake in either men or women. CONCLUSION: Sugars intake was associated with increased risk of colorectal cancer among smokers and non-alcohol drinkers in men selectively.
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spelling pubmed-40255862014-06-02 Sugars, sucrose and colorectal cancer risk: the Fukuoka colorectal cancer study Wang, Zhenjie Uchida, Kazuhiro Ohnaka, Keizo Morita, Makiko Toyomura, Kengo Kono, Suminori Ueki, Takashi Tanaka, Masao Kakeji, Yoshihiro Maehara, Yoshihiko Okamura, Takeshi Ikejiri, Koji Futami, Kitaroh Maekawa, Takafumi Yasunami, Yohichi Takenaka, Kenji Ichimiya, Hitoshi Terasaka, Reiji Scand J Gastroenterol Original Article OBJECTIVE: A diet high in sugars may promote colorectal carcinogenesis, but it remains uncertain whether high intake of sugars or sucrose confers increased risk of colorectal cancer. The authors investigated the associations of sugars and sucrose intake with colorectal cancer risk in a community-based case–control study in Japan. METHODS: The study subjects comprised 816 incident cases of colorectal cancer and 815 community controls. Consumption frequencies and portion sizes of 148 food and beverage items were ascertained by a computer-assisted interview. The authors used the consumption of 29 food items to estimate sugars and sucrose intake. The odds ratios of colorectal cancer risk according to intake categories were obtained using a logistic regression model with adjustment for potential confounding variables. RESULTS: Overall, intakes of sugars and sucrose were not related to colorectal cancer risk either in men or women. The association between sugars intake and colorectal cancer risk differed by smoking status and alcohol use in men, but not in women. In men, sugars intake tended to be associated with colorectal cancer risk inversely among never-smokers and positively among male ever-smokers (interaction p = 0.01). Sugars intake was associated with an increased risk among men with no alcohol consumption, but was unrelated to the risk among male alcohol drinkers (interaction p = 0.02). Body mass index did not modify the association with sugars intake in either men or women. CONCLUSION: Sugars intake was associated with increased risk of colorectal cancer among smokers and non-alcohol drinkers in men selectively. Informa Healthcare 2014-05 2014-04-09 /pmc/articles/PMC4025586/ /pubmed/24716480 http://dx.doi.org/10.3109/00365521.2013.822091 Text en © Informa Healthcare
spellingShingle Original Article
Wang, Zhenjie
Uchida, Kazuhiro
Ohnaka, Keizo
Morita, Makiko
Toyomura, Kengo
Kono, Suminori
Ueki, Takashi
Tanaka, Masao
Kakeji, Yoshihiro
Maehara, Yoshihiko
Okamura, Takeshi
Ikejiri, Koji
Futami, Kitaroh
Maekawa, Takafumi
Yasunami, Yohichi
Takenaka, Kenji
Ichimiya, Hitoshi
Terasaka, Reiji
Sugars, sucrose and colorectal cancer risk: the Fukuoka colorectal cancer study
title Sugars, sucrose and colorectal cancer risk: the Fukuoka colorectal cancer study
title_full Sugars, sucrose and colorectal cancer risk: the Fukuoka colorectal cancer study
title_fullStr Sugars, sucrose and colorectal cancer risk: the Fukuoka colorectal cancer study
title_full_unstemmed Sugars, sucrose and colorectal cancer risk: the Fukuoka colorectal cancer study
title_short Sugars, sucrose and colorectal cancer risk: the Fukuoka colorectal cancer study
title_sort sugars, sucrose and colorectal cancer risk: the fukuoka colorectal cancer study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025586/
https://www.ncbi.nlm.nih.gov/pubmed/24716480
http://dx.doi.org/10.3109/00365521.2013.822091
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