Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells

We show that expression of the microtubule depolymerizing kinesin KIF2C is induced by transformation of immortalized human bronchial epithelial cells by expression of K-Ras(G12V) and knockdown of p53. Further investigation demonstrates that this is due to the K-Ras/ERK1/2 MAPK pathway, as loss of p5...

Descripción completa

Detalles Bibliográficos
Autores principales: Zaganjor, Elma, Osborne, Jihan K., Weil, Lauren M., Diaz-Martinez, Laura A., Gonzales, Joshua X., Singel, Stina M., Larsen, Jill E., Girard, Luc, Minna, John D., Cobb, Melanie H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025984/
https://www.ncbi.nlm.nih.gov/pubmed/24240690
http://dx.doi.org/10.1038/onc.2013.486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025984/
https://www.ncbi.nlm.nih.gov/pubmed/24240690
http://dx.doi.org/10.1038/onc.2013.486

Ejemplares similares