Transformation by Hras(G12V) is Consistently Associated with Mutant Allele Copy Gains and is Reversed by Farnesyl Transferase Inhibition

RAS-driven malignancies remain a major therapeutic challenge. The two-stage 7,12-dimethylbenz(a)anthracene (DMBA)/12-o-tetradecanoylphorbol-13-acetate (TPA) model of mouse skin carcinogenesis has been used to study mechanisms of epithelial tumor development by oncogenic Hras. We used mice with a Hra...

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Detalles Bibliográficos
Autores principales: Chen, Xu, Makarewicz, Jacek M., Knauf, Jeffrey A., Johnson, Linda K., Fagin, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025988/
https://www.ncbi.nlm.nih.gov/pubmed/24240680
http://dx.doi.org/10.1038/onc.2013.489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025988/
https://www.ncbi.nlm.nih.gov/pubmed/24240680
http://dx.doi.org/10.1038/onc.2013.489

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