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SYK as a New Therapeutic Target in B-Cell Precursor Acute Lymphoblastic Leukemia
The identification of SYK as a master regulator of apoptosis controlling the activation of the PI3-K/AKT, NFκB, and STAT3 pathways—three major anti-apoptotic signaling pathways in B-lineage leukemia/lymphoma cells—prompts the hypothesis that rationally designed inhibitors targeting SYK may overcome...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026065/ https://www.ncbi.nlm.nih.gov/pubmed/24851191 http://dx.doi.org/10.4236/jct.2014.51015 |