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SYK as a New Therapeutic Target in B-Cell Precursor Acute Lymphoblastic Leukemia

The identification of SYK as a master regulator of apoptosis controlling the activation of the PI3-K/AKT, NFκB, and STAT3 pathways—three major anti-apoptotic signaling pathways in B-lineage leukemia/lymphoma cells—prompts the hypothesis that rationally designed inhibitors targeting SYK may overcome...

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Detalles Bibliográficos
Autores principales:	Uckun, Fatih M., Qazi, Sanjive
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026065/ https://www.ncbi.nlm.nih.gov/pubmed/24851191 http://dx.doi.org/10.4236/jct.2014.51015

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