LKB1 Loss Induces Characteristic Patterns of Gene Expression in Human Tumors Associated with NRF2 Activation and Attenuation of PI3K-AKT

INTRODUCTION: Inactivation of serine/threonine kinase 11 (STK11 or LKB1) is common in lung cancer, and understanding the pathways and phenotypes altered as a consequence will aid the development of targeted therapeutic strategies. Gene and protein expressions in a murine model of v-Ki-ras2 Kirsten r...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaufman, Jacob M., Amann, Joseph M., Park, Kyungho, Arasada, Rajeswara Rao, Li, Haotian, Shyr, Yu, Carbone, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026179/
https://www.ncbi.nlm.nih.gov/pubmed/24828662
http://dx.doi.org/10.1097/JTO.0000000000000173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026179/
https://www.ncbi.nlm.nih.gov/pubmed/24828662
http://dx.doi.org/10.1097/JTO.0000000000000173

Ejemplares similares