Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor

The human apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (APE1/Ref-1), an essential multifunctional protein involved in the repair of oxidative deoxyribonucleic acid (DNA) damage and transcriptional regulation, is often overexpressed in tumor tissues and cancer cells. Moreover, APE1/R...

Descripción completa

Detalles Bibliográficos
Autores principales: Qian, Chengyuan, Li, Mengxia, Sui, Jiangdong, Ren, Tao, Li, Zheng, Zhang, Liang, Zhou, Liwei, Cheng, Yi, Wang, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026309/
https://www.ncbi.nlm.nih.gov/pubmed/24872679
http://dx.doi.org/10.2147/DDDT.S62963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026309/
https://www.ncbi.nlm.nih.gov/pubmed/24872679
http://dx.doi.org/10.2147/DDDT.S62963

Ejemplares similares