Cargando…

Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor

The human apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (APE1/Ref-1), an essential multifunctional protein involved in the repair of oxidative deoxyribonucleic acid (DNA) damage and transcriptional regulation, is often overexpressed in tumor tissues and cancer cells. Moreover, APE1/R...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qian, Chengyuan, Li, Mengxia, Sui, Jiangdong, Ren, Tao, Li, Zheng, Zhang, Liang, Zhou, Liwei, Cheng, Yi, Wang, Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026309/ https://www.ncbi.nlm.nih.gov/pubmed/24872679 http://dx.doi.org/10.2147/DDDT.S62963

Ejemplares similares

Silencing of APE1 Enhances Sensitivity of Human Hepatocellular Carcinoma Cells to Radiotherapy In Vitro and in a Xenograft Model
por: Cun, Yanping, et al.
Publicado: (2013)

Bis-Cinnamamide Derivatives as APE/Ref-1 Inhibitors for the Treatment of Human Melanoma
por: Alhazmi, Razan, et al.
Publicado: (2022)

APE1/Ref-1 Role in Inflammation and Immune Response
por: Oliveira, Thais Teixeira, et al.
Publicado: (2022)

Elevation of Serum APE1/Ref-1 in Experimental Murine Myocarditis
por: Jin, Seon-Ah, et al.
Publicado: (2017)

APE1/Ref-1 as a Novel Target for Retinal Diseases
por: Heisel, Curtis, et al.
Publicado: (2021)

Identification of Novel Pathways Regulated by APE1/Ref-1 in Human Retinal Endothelial Cells
por: Mijit, Mahmut, et al.
Publicado: (2023)

APE1/Ref-1 Regulates STAT3 Transcriptional Activity and APE1/Ref-1–STAT3 Dual-Targeting Effectively Inhibits Pancreatic Cancer Cell Survival
por: Cardoso, Angelo A., et al.
Publicado: (2012)

The role of APE/Ref-1 signaling pathway in hepatocellular carcinoma progression
por: YANG, ZHEN, et al.
Publicado: (2014)

Urinary APE1/Ref-1: A Potential Bladder Cancer Biomarker
por: Choi, Sunga, et al.
Publicado: (2016)

Dynamic Regulation of APE1/Ref-1 as a Therapeutic Target Protein
por: Choi, Sunga, et al.
Publicado: (2016)

APE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer
por: Shin, Ju Hyun, et al.
Publicado: (2015)

APE1/Ref-1 as a Therapeutic Target for Inflammatory Bowel Disease
por: Sahakian, Lauren, et al.
Publicado: (2023)

New Horizons for the Roles and Association of APE1/Ref-1 and ABCA1 in Atherosclerosis
por: Chen, Wujun, et al.
Publicado: (2021)

Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function
por: Vascotto, Carlo, et al.
Publicado: (2011)

Plasma APE1/Ref-1 Correlates with Atherosclerotic Inflammation in ApoE(−/−) Mice
por: Lee, Yu Ran, et al.
Publicado: (2020)

Inhibition of APE1/Ref-1 for Neovascular Eye Diseases: From Biology to Therapy
por: Hartman, Gabriella D., et al.
Publicado: (2021)

Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer
por: Ren, Tao, et al.
Publicado: (2015)

Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1)
por: Jackson, Elias B., et al.
Publicado: (2005)

DNA Repair and Cancer Therapy: Targeting APE1/Ref-1 Using Dietary Agents
por: Raffoul, Julian J., et al.
Publicado: (2012)

APE1/Ref-1 – One Target with Multiple Indications: Emerging Aspects and New Directions
por: Mijit, Mahmut, et al.
Publicado: (2021)

Functional analysis of tanshinone IIA that blocks the redox function of human apurinic/apyrimidinic endonuclease 1/redox factor-1
por: Sui, Jiangdong, et al.
Publicado: (2014)

Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic
por: Shah, Fenil, et al.
Publicado: (2017)

ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1
por: Lee, Yu Ran, et al.
Publicado: (2019)

Practical Strategy to 1,1′-Dideoxygossypol Derivatives from Gossypol and Its Antitumor Activities
por: Wang, Wei, et al.
Publicado: (2022)

Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of Cysteines 93 and 310
por: Qu, Jing, et al.
Publicado: (2007)

APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions
por: Thakur, Shweta, et al.
Publicado: (2014)

Elevated APE1/Ref-1 Levels of Synovial Fluids in Patients with Rheumatoid Arthritis: Reflection of Disease Activity
por: Yoo, In Seol, et al.
Publicado: (2021)

Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells
por: Sriramajayam, Kannappan, et al.
Publicado: (2021)

Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival
por: Logsdon, Derek P., et al.
Publicado: (2018)

Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP
por: Pines, Alex, et al.
Publicado: (2005)

Transcriptional Up-Regulation of APE1/Ref-1 in Hepatic Tumor: Role in Hepatocytes Resistance to Oxidative Stress and Apoptosis
por: Di Maso, Vittorio, et al.
Publicado: (2015)

APE1/Ref-1 Inhibits Phosphate-Induced Calcification and Osteoblastic Phenotype Changes in Vascular Smooth Muscle Cells
por: Lee, Ki Mo, et al.
Publicado: (2017)

Dual Regulatory Roles of Human AP-Endonuclease (APE1/Ref-1) in CDKN1A/p21 Expression
por: Sengupta, Shiladitya, et al.
Publicado: (2013)

APE1/Ref-1 Inhibits Adipogenic Transcription Factors during Adipocyte Differentiation in 3T3-L1 Cells
por: Lee, Eun-Ok, et al.
Publicado: (2023)

Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides
por: Lau, J P, et al.
Publicado: (2004)

Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage
por: Zaky, Amira, et al.
Publicado: (2008)

Altered Secretory Activity of APE1/Ref-1 D148E Variants Identified in Human Patients With Bladder Cancer
por: Lee, Yu Ran, et al.
Publicado: (2016)

Dual Function of Secreted APE1/Ref-1 in TNBC Tumorigenesis: An Apoptotic Initiator and a Regulator of Chronic Inflammatory Signaling
por: Choi, Sunga, et al.
Publicado: (2022)

Secreted APE1/Ref-1 inhibits TNF-α-stimulated endothelial inflammation via thiol-disulfide exchange in TNF receptor
por: Park, Myoung Soo, et al.
Publicado: (2016)

Therapeutic positioning of secretory acetylated APE1/Ref-1 requirement for suppression of tumor growth in triple-negative breast cancer in vivo
por: Lee, Yu Ran, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_gi9uepvpohrjiptc5mqorafq5p