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P-glycoprotein- and organic anion-transporting polypeptide-mediated transport of periplocin may lead to drug–herb/drug–drug interactions
Periplocin, an active and toxic component of the traditional Chinese herbal medicine Periploca sepium Bge, is a cardiac glycoside compound that has been implicated in various clinical accidents. This study investigated the role of transporters in the intestinal absorption and biliary excretion of pe...
Autores principales: | Liang, Sheng, Deng, Fengchun, Xing, Haiyan, Wen, He, Shi, Xiaoyan, Martey, Orleans Nii, Koomson, Emmanuel, He, Xin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026310/ https://www.ncbi.nlm.nih.gov/pubmed/24872678 http://dx.doi.org/10.2147/DDDT.S61024 |
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