Hypoxia-Mediated Mechanism of MUC5AC Production in Human Nasal Epithelia and Its Implication in Rhinosinusitis

BACKGROUND: Excessive mucus production is typical in various upper airway diseases. In sinusitis, the expression of MUC5AC, a major respiratory mucin gene, increases. However, the mechanisms leading to mucus hypersecretion in sinusitis have not been characterized. Hypoxia due to occlusion of the sin...

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Detalles Bibliográficos
Autores principales: Kim, Yoon-Ju, Cho, Hyung-Ju, Shin, Woo-Chul, Song, Hyun-Ah, Yoon, Joo-Heon, Kim, Chang-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026485/
https://www.ncbi.nlm.nih.gov/pubmed/24840724
http://dx.doi.org/10.1371/journal.pone.0098136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026485/
https://www.ncbi.nlm.nih.gov/pubmed/24840724
http://dx.doi.org/10.1371/journal.pone.0098136

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