Integration of In Vitro Binding Mechanism Into the Semiphysiologically Based Pharmacokinetic Interaction Model Between Ketoconazole and Midazolam

In vitro screening for drug–drug interactions is an integral component of drug development, with larger emphasis now placed on the use of in vitro parameters to predict clinical inhibition. However, large variability exists in K(i) reported for ketoconazole with midazolam, a model inhibitor–substrat...

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Detalles Bibliográficos
Autores principales: Quinney, Sara K., Knopp, Shawn, Chang, Chien, Hall, Stephen D., Li, Lang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026634/
https://www.ncbi.nlm.nih.gov/pubmed/24448021
http://dx.doi.org/10.1038/psp.2013.50

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026634/
https://www.ncbi.nlm.nih.gov/pubmed/24448021
http://dx.doi.org/10.1038/psp.2013.50

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