Imputation of TPMT defective alleles for the identification of patients with high-risk phenotypes

Background: The activity of thiopurine methyltransferase (TPMT) is subject to genetic variation. Loss-of-function alleles are associated with various degrees of myelosuppression after treatment with thiopurine drugs, thus genotype-based dosing recommendations currently exist. The aim of this study w...

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Detalles Bibliográficos
Autores principales: Almoguera, Berta, Vazquez, Lyam, Connolly, John J., Bradfield, Jonathan, Sleiman, Patrick, Keating, Brendan, Hakonarson, Hakon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026736/
https://www.ncbi.nlm.nih.gov/pubmed/24860591
http://dx.doi.org/10.3389/fgene.2014.00096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026736/
https://www.ncbi.nlm.nih.gov/pubmed/24860591
http://dx.doi.org/10.3389/fgene.2014.00096

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