The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast

DNA double-strand breaks (DSBs) can cause chromosomal rearrangements and extensive loss of heterozygosity (LOH), hallmarks of cancer cells. Yet, how such events are normally suppressed is unclear. Here we identify roles for the DNA damage checkpoint pathway in facilitating homologous recombination (...

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Detalles Bibliográficos
Autores principales: Blaikley, Elizabeth J., Tinline-Purvis, Helen, Kasparek, Torben R., Marguerat, Samuel, Sarkar, Sovan, Hulme, Lydia, Hussey, Sharon, Wee, Boon-Yu, Deegan, Rachel S., Walker, Carol A., Pai, Chen-Chun, Bähler, Jürg, Nakagawa, Takuro, Humphrey, Timothy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027169/
https://www.ncbi.nlm.nih.gov/pubmed/24623809
http://dx.doi.org/10.1093/nar/gku190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027169/
https://www.ncbi.nlm.nih.gov/pubmed/24623809
http://dx.doi.org/10.1093/nar/gku190

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