Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex

MUS81 shares a high-degree homology with the catalytic XPF subunit of the XPF–ERCC1 endonuclease complex. It is catalytically active only when complexed with the regulatory subunits Mms4 or Eme1 in budding and fission yeasts, respectively, and EME1 or EME2 in humans. Although Mus81 complexes are imp...

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Detalles Bibliográficos
Autores principales: Amangyeld, Tamir, Shin, Yong-Keol, Lee, Miju, Kwon, Buki, Seo, Yeon-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027171/
https://www.ncbi.nlm.nih.gov/pubmed/24692662
http://dx.doi.org/10.1093/nar/gku237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027171/
https://www.ncbi.nlm.nih.gov/pubmed/24692662
http://dx.doi.org/10.1093/nar/gku237

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