Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction

We report alterations to the murine leukemia virus (MLV) integrase (IN) protein that successfully result in decreasing its integration frequency at transcription start sites and CpG islands, thereby reducing the potential for insertional activation. The host bromo and extraterminal (BET) proteins Br...

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Detalles Bibliográficos
Autores principales: Aiyer, Sriram, Swapna, G.V.T., Malani, Nirav, Aramini, James M., Schneider, William M., Plumb, Matthew R., Ghanem, Mustafa, Larue, Ross C., Sharma, Amit, Studamire, Barbara, Kvaratskhelia, Mamuka, Bushman, Frederic D., Montelione, Gaetano T., Roth, Monica J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027182/
https://www.ncbi.nlm.nih.gov/pubmed/24623816
http://dx.doi.org/10.1093/nar/gku175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027182/
https://www.ncbi.nlm.nih.gov/pubmed/24623816
http://dx.doi.org/10.1093/nar/gku175

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