Fail-safe mechanism of GCN4 translational control—uORF2 promotes reinitiation by analogous mechanism to uORF1 and thus secures its key role in GCN4 expression

One of the extensively studied mechanisms of gene-specific translational regulation is reinitiation. It takes place on messenger RNAs (mRNAs) where main ORF is preceded by upstream ORF (uORF). Even though uORFs generally down-regulate main ORF expression, specific uORFs exist that allow high level o...

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Detalles Bibliográficos
Autores principales: Gunišová, Stanislava, Valášek, Leoš Shivaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027193/
https://www.ncbi.nlm.nih.gov/pubmed/24623812
http://dx.doi.org/10.1093/nar/gku204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027193/
https://www.ncbi.nlm.nih.gov/pubmed/24623812
http://dx.doi.org/10.1093/nar/gku204

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