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Inferring probabilistic miRNA–mRNA interaction signatures in cancers: a role-switch approach

Aberrant microRNA (miRNA) expression is implicated in tumorigenesis. The underlying mechanisms are unclear because the regulations of each miRNA on potentially hundreds of mRNAs are sample specific. We describe a novel approach to infer Probabilistic MiRNA–mRNA Interaction Signature (‘ProMISe’) from...

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Detalles Bibliográficos
Autores principales: Li, Yue, Liang, Cheng, Wong, Ka-Chun, Jin, Ke, Zhang, Zhaolei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027195/
https://www.ncbi.nlm.nih.gov/pubmed/24609385
http://dx.doi.org/10.1093/nar/gku182