Mechanistic insight into ligand binding to G-quadruplex DNA

Specific guanine-rich regions in human genome can form higher-order DNA structures called G-quadruplexes, which regulate many relevant biological processes. For instance, the formation of G-quadruplex at telomeres can alter cellular functions, inducing apoptosis. Thus, developing small molecules tha...

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Detalles Bibliográficos
Autores principales: Di Leva, Francesco Saverio, Novellino, Ettore, Cavalli, Andrea, Parrinello, Michele, Limongelli, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027208/
https://www.ncbi.nlm.nih.gov/pubmed/24753420
http://dx.doi.org/10.1093/nar/gku247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027208/
https://www.ncbi.nlm.nih.gov/pubmed/24753420
http://dx.doi.org/10.1093/nar/gku247

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