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Mechanistic insight into ligand binding to G-quadruplex DNA
Specific guanine-rich regions in human genome can form higher-order DNA structures called G-quadruplexes, which regulate many relevant biological processes. For instance, the formation of G-quadruplex at telomeres can alter cellular functions, inducing apoptosis. Thus, developing small molecules tha...
Autores principales: | Di Leva, Francesco Saverio, Novellino, Ettore, Cavalli, Andrea, Parrinello, Michele, Limongelli, Vittorio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027208/ https://www.ncbi.nlm.nih.gov/pubmed/24753420 http://dx.doi.org/10.1093/nar/gku247 |
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