Solution structure of a 2:1 complex of anticancer drug XR5944 with TFF1 estrogen response element: insights into DNA recognition by a bis-intercalator

XR5944, a deoxyribonucleic acid (DNA) bis-intercalator with potent anticancer activity, can bind the estrogen response element (ERE) sequence to inhibit estrogen receptor-α activities. This novel mechanism of action may be useful for overcoming drug resistance to currently available antiestrogen tre...

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Detalles Bibliográficos
Autores principales: Lin, Clement, Mathad, Raveendra I., Zhang, Zhenjiang, Sidell, Neil, Yang, Danzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027214/
https://www.ncbi.nlm.nih.gov/pubmed/24711371
http://dx.doi.org/10.1093/nar/gku219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027214/
https://www.ncbi.nlm.nih.gov/pubmed/24711371
http://dx.doi.org/10.1093/nar/gku219

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