A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair

DNA double-strand breaks (DSBs) are the most severe type of DNA damage. DSBs are repaired by non-homologous end-joining or homology directed repair (HDR). Identifying novel small molecules that affect HDR is of great importance both for research use and therapy. Molecules that elevate HDR may improv...

Descripción completa

Detalles Bibliográficos
Autores principales: Shahar, Or David, Kalousi, Alkmini, Eini, Lital, Fisher, Benoit, Weiss, Amelie, Darr, Jonatan, Mazina, Olga, Bramson, Shay, Kupiec, Martin, Eden, Amir, Meshorer, Eran, Mazin, Alexander V., Brino, Laurent, Goldberg, Michal, Soutoglou, Evi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027216/
https://www.ncbi.nlm.nih.gov/pubmed/24682826
http://dx.doi.org/10.1093/nar/gku217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027216/
https://www.ncbi.nlm.nih.gov/pubmed/24682826
http://dx.doi.org/10.1093/nar/gku217

Ejemplares similares