Long-term Expression of Apolipoprotein B mRNA-specific Hammerhead Ribozyme via scAAV8.2 Vector Inhibits Atherosclerosis in Mice

Target substrate-specific hammerhead ribozyme cleaves the specific mRNA efficiently and results in the inhibition of gene expression. In humans, overproduction of apolipoprotein B (apoB) is positively associated with premature coronary artery diseases. The goal of this study is to demonstrate that l...

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Detalles Bibliográficos
Autores principales: Nischal, Hersharan, Sun, Hua, Wang, Yuchun, Ford, David A, Cao, Ying, Wei, Peng, Teng, Ba-Bie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027429/
https://www.ncbi.nlm.nih.gov/pubmed/24084845
http://dx.doi.org/10.1038/mtna.2013.53

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027429/
https://www.ncbi.nlm.nih.gov/pubmed/24084845
http://dx.doi.org/10.1038/mtna.2013.53

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