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Mg(2+) block properties of triheteromeric GluN1–GluN2B–GluN2D NMDA receptors on neonatal rat substantia nigra pars compacta dopaminergic neurones

Native NMDA receptors (NMDARs) are tetrameric channels formed by two GluN1 and two GluN2 subunits. So far, seven NMDARs subunits have been identified and they can form diheteromeric or triheteromeric NMDARs (more than one type of GluN2 subunit). Extracellular Mg(2+) is an important regulator of NMDA...

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Detalles Bibliográficos
Autores principales: Huang, Zhuo, Gibb, Alasdair J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027860/
https://www.ncbi.nlm.nih.gov/pubmed/24614743
http://dx.doi.org/10.1113/jphysiol.2013.267864