Na(v)1.1 Modulation by a Novel Triazole Compound Attenuates Epileptic Seizures in Rodents

[Image: see text] Here, we report the discovery of a novel anticonvulsant drug with a molecular organization based on the unique scaffold of rufinamide, an anti-epileptic compound used in a clinical setting to treat severe epilepsy disorders such as Lennox-Gastaut syndrome. Although accumulating evi...

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Detalles Bibliográficos
Autores principales: Gilchrist, John, Dutton, Stacey, Diaz-Bustamante, Marcelo, McPherson, Annie, Olivares, Nicolas, Kalia, Jeet, Escayg, Andrew, Bosmans, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027953/
https://www.ncbi.nlm.nih.gov/pubmed/24635129
http://dx.doi.org/10.1021/cb500108p

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027953/
https://www.ncbi.nlm.nih.gov/pubmed/24635129
http://dx.doi.org/10.1021/cb500108p

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