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PAR2-mediated upregulation of BDNF contributes to central sensitization in bone cancer pain

BACKGROUND: Bone cancer pain is currently a major clinical challenge for the management of cancer patients, and the cellular and molecular mechanisms underlying the spinal sensitization remain unclear. While several studies demonstrated the critical role of proteinase-activated receptor (PAR2) in th...

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Detalles Bibliográficos
Autores principales: Bao, Yanju, Hou, Wei, Liu, Rui, Gao, Yebo, Kong, Xiangying, Yang, Liping, Shi, Zhan, Li, Weidong, Zheng, Honggang, Jiang, Shulong, Li, Conghuang, Qin, Yinggang, Hua, Baojin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027994/
https://www.ncbi.nlm.nih.gov/pubmed/24886294
http://dx.doi.org/10.1186/1744-8069-10-28