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PAR2-mediated upregulation of BDNF contributes to central sensitization in bone cancer pain
BACKGROUND: Bone cancer pain is currently a major clinical challenge for the management of cancer patients, and the cellular and molecular mechanisms underlying the spinal sensitization remain unclear. While several studies demonstrated the critical role of proteinase-activated receptor (PAR2) in th...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027994/ https://www.ncbi.nlm.nih.gov/pubmed/24886294 http://dx.doi.org/10.1186/1744-8069-10-28 |