Efficient Selection of Genetically Modified Human T Cells Using Methotrexate-Resistant Human Dihydrofolate Reductase

Genetic modification of human T cells to express transgene-encoded polypeptides, such as tumor targeting chimeric antigen receptors, is an emerging therapeutic modality showing promise in clinical trials. The development of simple and efficient techniques for purifying transgene(+) T cells is needed...

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Detalles Bibliográficos
Autores principales: Jonnalagadda, Mahesh, Brown, Christine E., Chang, Wen C., Ostberg, Julie R., Forman, Stephen J., Jensen, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028078/
https://www.ncbi.nlm.nih.gov/pubmed/23303282
http://dx.doi.org/10.1038/gt.2012.97

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028078/
https://www.ncbi.nlm.nih.gov/pubmed/23303282
http://dx.doi.org/10.1038/gt.2012.97

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