Nuclear localization signal deletion mutants of lamin A and progerin reveal insights into lamin A processing and emerin targeting

Lamin A is a major component of the lamina, which creates a dynamic network underneath the nuclear envelope. Mutations in the lamin A gene (LMNA) cause severe genetic disorders, one of which is Hutchinson-Gilford progeria syndrome (HGPS), a disease triggered by a dominant mutant named progerin. Unli...

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Detalles Bibliográficos
Autores principales: Wu, Di, Flannery, Andrew R, Cai, Helen, Ko, Eunae, Cao, Kan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028357/
https://www.ncbi.nlm.nih.gov/pubmed/24637396
http://dx.doi.org/10.4161/nucl.28068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028357/
https://www.ncbi.nlm.nih.gov/pubmed/24637396
http://dx.doi.org/10.4161/nucl.28068

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