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Nuclear localization signal deletion mutants of lamin A and progerin reveal insights into lamin A processing and emerin targeting
Lamin A is a major component of the lamina, which creates a dynamic network underneath the nuclear envelope. Mutations in the lamin A gene (LMNA) cause severe genetic disorders, one of which is Hutchinson-Gilford progeria syndrome (HGPS), a disease triggered by a dominant mutant named progerin. Unli...
Autores principales: | Wu, Di, Flannery, Andrew R, Cai, Helen, Ko, Eunae, Cao, Kan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028357/ https://www.ncbi.nlm.nih.gov/pubmed/24637396 http://dx.doi.org/10.4161/nucl.28068 |
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